Pathogens and Their Weaponization. Geoffrey Zubay. Columbia University Press . Agents of Bioterrorism. Google Preview. Pub Date: February Download Citation on ResearchGate | On Jan 1, , Geoffrey Zubay and others published Agents of Bioterrorism: Pathogens and their Weaponization }. [Book Review: Agents of Bioterrorism: Pathogens and Their Weaponization.] Article in The Quarterly Review of Biology 81(3) · September with 5.

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Although the head louse P. ZubayProfessor Geoffrey Zubay. In short, mass propagation of rickettsial pathogens and their purification and aerosolization remain a major challenge. Because of their unique biological characteristics environmental stability, small size, aerosol transmission, persistence in infected hosts, low infectious dose, high morbidity, and substantial mortalityR.

Molecular detection of tick-borne pathogens in canine population and Rhipicephalus sanguineus sensu lato ticks from southern Metro Manila and Laguna, Philippines. Initiating the proper treatment and curtailing outbreaks is the most crucial step, because prompt initiation of antibiotic treatment would prevent people from becoming ill and from dying. The authors examine thirteen disease-causing agents, including those responsible for anthrax, the plague, smallpox, influenza, and SARS.

This new work offers a clear and thorough account of the threats posed by bioterrorism from the perspective of biologists. Please check for further notifications by email. Drug Discovery and Biodefense. Zubay Limited preview – Comparison of selected rickettsial pathogens with examples of bacteria used in biological warfare. The sudden occurrence of a few human cases in areas of nonendemicity could set off the alarm. Citing articles via Web of Science Surveillance of naturally or intentionally released pathogens is a first step in preventing the epidemics via rapid identification of causative agents and assessing the degree of their virulence.


Each chapter considers a particular pathogen from the standpoint of its history, molecular biology, pathology, clinical presentation, diagnosis, weaponization, and defenses. The Challenge Of Rickettsial Pathogens. Contents How to Cope I. In recent years, increased awareness and proper treatment and care have had a great impact on reducing case-fatality rates associated with rickettsial diseases.

Bioterrorism: pathogens as weapons.

The book also examines strategies for making vaccines and protecting the population in a bioterror attack. The virulent strains of both C. Woodward, bioterrorosm his insightful contributions to our knowledge of epidemic and murine typhus. Abstract Because of their unique biological characteristics, such as environmental stability, small size, aerosol transmission, persistence in infected hosts, low infectious dose, and high associated morbidity and mortality, Rickettsia prowazekii and Coxiella burnetii have been weaponized.

Each chapter considers a particular pathogen Receive exclusive offers and updates from Oxford Academic. Intentional release of R. Rickettsial aerosolization would provide an additional compounding factor, because it requires both a high degree of scientific expertise and a well-equipped, rather sophisticated facility.


These biological boiterrorism would make the pathogenic rickettsiae desirable bioterrorism agents.

Rickettsioses are a good example of diseases whose importance is not adequately appreciated, except by patients. Sign In or Create an Account. He has published more than research papers and several books, including Biochemistry ; Genetics ; and Origins of Life on the Earth and in the Cosmos.

Close mobile search navigation Article navigation. Thrombosis of the small vessels in the extremities may produce gangrene and necrosis. In addition, acquisition of rickettsial pathogens from reservoir hosts would be a daunting task requiring time-consuming protocols to obtain pure and weaponizahion isolates.

Bioterrorism: pathogens as weapons.

In contrast to pathogems explosive nature of outbreaks of louseborne typhus, sporadic but limited outbreaks of louseborne typhus and other rickettsial diseases have been reported throughout the world. During later stages of infection, patients appear to be delirious and exhibit neurologic symptoms, including stupor.

Epidemics of louseborne typhus, plague, influenza, and dysentery have been important in the shaping of human destiny and have caused more deaths than all the wars throughout history [ 123—4 ]. Columbia University Press Weaponizaion.