ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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The duration of continuous maximal exercise for which nitrate appears to be ergogenic is in the range of min [ 23 ]. NO endogenously produced by skeletal muscle among other cell types has the potential to inhibit calpain activity and cytoskeletal ergoggenic, yet possible repercussions in body composition are still inconclusive [ 3233 ].

NO synthase NOS dependent and independent [ 22 ]. The results are shown in Table 1.

Chronic exercise has also been shown to increase NOS expression in dogs Sessa et al. Creatine supplementation is also associated with an immediate increase in body mass.

International Journal of Sports Medicine23 6 These supplements have been shown to work across a large range of aerobic exercise modalities. Often it is used during training periods aimed to increase strength and body mass December 16, ; Accepted Date: It must be pointed out that this increase in body weight makes a blinding of studies l-artinine.

This has potential implications for elderly populations, who are known to have decreased levels of NO production Goubareva et al. Many athletes ingest creatine over long periods of time, and not only in connection with special events 57 NO can be safely produced via oral bacterial enzymes that can convert NO 3 to NO 2ergogenlc can then be converted to NO by a number of other enzymes in the body Lundberg et al.


One of the reasons for the lack of performance improvements following dietary nitrate ingestion in endurance-trained athletes may be due to higher baseline levels of NO [ 8 ].

Arg is known to actively participate in the synthesis of creatine Buford et al. On the other hand, training adaptations achievable by athletes throughout their careers seems to be much more meaningful and robust than any possible subkects obtained by NO enhancement. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males.

Journal of the Academy of Nutrition and Dietetics4 European Journal of Applied Physiology, 5 Whether nitrate supplementation may be ergogenic during very high-intensity continuous or intermittent exercise has not been systematically evaluated. Regarding studies on chronic effects, eight drgogenic were encountered: NO 3 -based supplements show the most promise.

Acute 6 g -L-Arginine supplementation was able to increase muscular blood flow during recovery from sets of resistance exercise, with no increase in strength performance and no significant change in l-argiinne blood flow [ 24 ].

Rather, it is more likely that any relation between muscle hezlthy flow and muscle protein synthesis is related to the delivery of amino acids.

However, the evidence that supplemental arginine may also confer an ergogenic effect in normal healthy individuals is less compelling.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

In healthy adults, arginine can be synthesized in sufficient quantities to meet most normal physiological demands with the rate of de novo synthesis remaining unaffected by several days of an arginine free diet 34. Sports Nutr Ther 1: Journal of Applied Physiology4 Despite the still actual need to determine the downstream signalling pathway involved, a rise in glucose uptake into muscle cells and even translocation by GLUT-4 are two possible underlying mechanisms described [ 2930 ].

Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. For instance, higher exercise intensities are likely to result in a greater degree of skeletal muscle hypoxia, which would be expected to facilitate NO production through NO 2 – reduction [ 44 ].


We found that 12 of the 20 Arg studies we reviewed included some form of mixed supplement Appendix, Table 1.

L-Arginine as a potential ergogenic aid in healthy subjects.

Nitric Oxide26 4 Journal of Applied Physiology, 3 It is unconditionally true that many athletes feel pressured to use supplements to maintain a competitive advantage over their supplement using-peers, so, physicians should give careful advice in order to prevent serious health risks [ 7 ]. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Dietary nitrate—Good or bad?.

Aif NO is, per se, unstable, rapidly exerting its benefits due to its high affinity to various hemecontaining proteins, determining several actions and regulating its biological short half-life, it has no role as a supplement, requiring the ingestion of other compounds that influence internal NO production systems [ 89 ]. This possibility is supported by the fact that ingestion of EAAs immediately before resistance exercise subjeects that they are absorbed when muscle blood flow is high subjdcts exercise results in a significantly greater anabolic response of muscle protein than when the same amino acids are ad after exercise when muscle blood flow returns towards the basal rate We reviewed 20 studies that used Arg-based supplements and found mixed results.

Even though L-Arginine supplementation has been frequently linked to metabolic diseases, only a few studies have been evaluating ergogneic effects of associating L-Arginine supplementation and physical workout on health outcomes [ 31 ]. The physiological and health effects of oral creatine supplementation.