1. Eur Ann Otorhinolaryngol Head Neck Dis. Feb;(1) doi: / Epub Jul 9. A case of an ameloblastic fibrosarcoma in the mandible is described. The primary tumor was seen in a 5-year-old child. In spite of repeated surgical. Introduction. Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent.

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In this article, we reported a case of maxillary AFS.

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

A year-old man, educated in an engineering field, from a city in North of Iran was referred to School of Dentistry of Tehran University of Medical Sciences by an oral and maxillofacial surgeon OMFS for oral pathology consultation in winter of There is also a lack of data on the effects amelolastic the sarcomatous component of the lesion on proliferative activity and differentiation aspects of the ameloblastic epithelium present in AFS.

Immunolocalization of the p53 protein in a case of ameloblastic fibrosarcoma. Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. As expected, the pain persisted and healing of the extraction site was not normal.

The posterior mandible is the most commonly affected site [ 8 ]. Treatment was prescribed for only one case and the patient was disease-free for 18 months after diagnosis. Restricted molecular abnormalities of certain genes to the malignant transformation. Ameloblastic fibroma and ameloblastic sarcoma–a report of the cases, histopathology and histochemistry.


Abstract Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. Most of the lesions presented large mean, 5. Rare, More common in males 1. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

J Oral Maxillofac Pathol ; Ameloblastic fibrosarcoma Ameloblastic fibrodentinosarcoma: A study of cases. Both neoplasms have a biphasic nature; however, AF has no malignant component, unlike AFS in which the mesenchymal component presents marked cellularity, nuclear pleomorphism, hyperchromatism, and a moderate to high number of mitotic figures.

AFS is the most common of them 66. Radiographs show a radiolucent mass with ill-defined borders. Ameloblastic fibrosarcoma involving the anterior and middle skull base with intradural extension. Acta Med Scand ; Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: J Craniofac Surg ; Ameloblastic fibrosarcoma of the jaw: Ameloblastic fibrosarcoma, maxilla, odontogenic tumor. Zwei differential diagnostisch wichtige Unterkiefertumoren, Adamantinoma sarkomatodes und Wurzelzyste des Unterkiefers.

Therefore, a more serious process was suspected and the patient was referred to an OMFS for further examination.

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

Int J Oral Surg ;5: PCNA was strongly positive in both components, while p53 was strongly positive only in the mesenchymal component. B Marked pleomorphism in odontogenic ectomesenchyme adjacent to an epithelial island. The patient complained of pain and dysphagia for 4 months.


Plain radiographic examinations showed an ill-demarcated and partially corticated multilocular radiolucency affecting the left posterior mandible. AFS is a locally aggressive malignant tumor, with regional and distant metastases being uncommon. Cases first treated with a conservative approach have demonstrated lower overall survival, mainly because of multiple relapses and the involvement of other structures Table 3 and Fig. Case Rep Pathol ; All these components are included in a highly cellular malignant connective stromal component, with cells showing variable amelpblastic of anaplasia 1.

The usual clinical presentation consists of a patient who complains of a painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia. J Oral Pathol Med. A highly malignant ameloblastic fibrosarcoma. The clinical, radiographic, and histopathological features were described in addition to the patient’s management and present status.

The following search terms were used: Report of a rare case with long-term follow-up. Foi realizado imunohistoquimica para marcadores epiteliais, mesenquimais e do ciclo celular. The majority of reported cases have ameloblaastic found in the posterior region of mandible and rarely maxillary involvement is indicated. J Pediatr Hematol Oncol ; Open in a separate window.

Ameloblastic fibrosarcoma [title] mandible. Click here for information on linking to our website or using our content or images. The malignant sarcomatous component showed positivity only for vimentin, demonstrating no apparent transdifferentiation signal.