by. Ana Sirley Calderon Flores. on 11 November Comments (0). Please log in to add your comment. Report abuse. Transcript of ANEMIA MACROCITICA. Megaloblastosis can be associated with severe anemia and pancytopenia, gastrointestinal dysfunction and glossitis, personality changes. Macrocytosis without anemia may be a normal variant and is only noted as a result of repeated peripheral RBC indices in the absence of any known or existing.

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Long-term treatment is not warranted except with chronic conditions such as malnutrition, exfoliative dermatitis or hemolysis.

Any anemia in which the average size of circulating erythrocytes is greater than normal, the mean macrocirica volume is 94 mcm[supscript 3] or more normal range, mcm [supscript 3]including such syndromes as pernicious anemia, sprue, celiac disease, macrocytic anemia of pregnancy, anemia of diphyllobothriasis.

Drugs Alcoholism Reticulocytosis Nonalcoholic and alcoholic liver disease Hypothyroidism Vitamin B12 deficiency Folate deficiency Multiple myeloma Myelodysplastic syndromes Aplastic anemia Acute leukemia.

ANEMIA MACROCITICA by Ana Sirley Calderon Flores on Prezi

A full hematologic response should occur within macrocutica weeks. Esprue Tropical y No Tropical. Clinical Significance Macrocytosis is a relatively common finding in the era of automated blood cell counters, with prevalence estimates ranging from 1.

However, the metabolism of L-methylmalonyl CoA to succinyl CoA, an enzymatic pathway involved in oxidative phosphorylation reactions macrrocitica the cell, only requires vitamin B National Center for Biotechnology InformationU.

Macrocytic anemia can usually be divided into two categories, megaloblastic and nonmegaloblastic, based on wnemia examination of the bone marrow. Macfocitica un comentario Este es un blog dirigido a profesionales sanitarios. Change the order of display of the official languages of Canada English first French first Option to display the non-official languages Spanish or Portuguese Macricitica Spanish Portuguese Display definitions, contexts, etc.

Hereditary spherocytosis Minkowski—Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis. The authors are grateful to Marian Menn and Veronica Tillema for providing the figures of macrocytosis in the peripheral blood smear. RBC folate levels remain constant throughout the lifespan of the cell and are not affected by short-term dietary changes that can alter serum levels. This constellation of events eventually leads to pernicious anemia and requires prompt intervention with exogenous vitamin B12 preparations.


These abnormalities are caused by a defect in DNA synthesis that interferes with cellular proliferation and maturation. Investigation of Macrocytosis The evaluation of the patient with macrocytosis requires a systemic approach.

Due to the lack of available radioactive Vitamin B 12the Schilling test is now largely a historical artifact.

A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. Gross S, Roath S, eds. Glossaries and vocabularies Access Translation Bureau glossaries and vocabularies.

Megaloblastic Anemia and Other Causes of Macrocytosis

Find articles by Florence Aslinia. Because of the high concentration of folate within the RBC, mild degrees of hemolysis can falsely elevate serum folate levels.

Acknowledgments The authors are grateful to Marian Menn and Veronica Tillema for providing the figures of macrocytosis in the peripheral blood smear. Se han descrito casos coincidentes en el mismo domicilio. Evidence-Based Gastroenterology ; 5: Serum MMA will be elevated in patients with underlying renal dysfunction, decreasing its specificity and sensitivity in identifying patients with cobalamin deficiency.

Tisman G, Herbert V. Megaloblastic anemia Pernicious anemia. It is imperative that a hematologist or hematopathologist examine the marrow in order to appreciate these important, subtle, hematopoietic abnormalities. However, assays for measuring RBC folate levels have also been fraught with unreliability.

Curr Opin Gastroenterol ; In folate deficiency patients, serum homocysteine levels are markedly increased, while serum MMA levels are not elevated. Evaluation of macrocytosis begins with a complete history and physical examination to search for signs and symptoms related to an acute or chronic underlying illness that may be obvious or occult in nature.


However, its identification can provide important information regarding the presence of an underlying disease state.

Direct measurement of blood cobalamin remains the gold standard because the test for elevated methylmalonic acid is not specific enough. The evaluation of the patient with macrocytosis requires a systemic approach.

Macrocytosis is the earliest abnormality seen in complete blood counts of patients with folate or vitamin B12 deficiency. Epidemiologia Se estima que la incidencia de la pitiriasis rosada macroccitica de alrededor de por Please review the contents of the article and add the appropriate references if you can.

Anemia MacrocĂ­tica by lilian camargo on Prezi

In folate deficiency, the serum folate level is very sensitive to dietary folate intake and responds well to short-term treatment. Effective treatment of cobalamin deficiency with oral cobalamin. Although determination of the MCV by automated blood cell counter is rarely inaccurate, hyperglycemia, marked leukocytosis and cold agglutinins may result in false elevations of znemia MCV.

The hydroxylated form of cobalamin plays an important role in the metabolism of homocysteine and MMA. This leads to continuing cell growth without division, which presents as macrocytosis.

Oral versus intramuscular cobalamin treatment in megaloblastic anemia: Megaloblastic anemia or megaloblastic anaemia is an anemia of macrocytic classification that results from inhibition of DNA synthesis during red blood cell production.

Clin Lab Med ; Existen tres tipos de trascobalaminas: Existen tres picos de mayor prevalencia: Harvard University Press; From Wikipedia, the free encyclopedia. A measurement of methylmalonic acid methylmalonate can provide an indirect method for partially differentiating Vitamin B 12 and folate deficiencies. Chanarin I, Metz J. En la tabla I se resumen las causas de deficiencia de vitamina B