British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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British anti-Lewisite (dimercaprol): an amazing history.

Help us improve this article! Contact our editors with your feedback. Unfortunately, our editorial approach may not be able to accommodate all contributions. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided.

Your contribution may be further edited by our staff, and lweisite publication is subject to our final approval. Because of its instability in water, it is administered by intramuscular injection of a solution of it in peanut oil.

InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter However, it is not necessarily the treatment of choice for toxicity to these metals.


The content you are trying to view is available only to logged in, current MedLink Neurology subscribers. Dimercaprol Skeletal formula and ball and stick model of dimercaprol.

It is a potentially toxic drug, and its use may lewsiite accompanied by multiple side effects. Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs.

British anti-Lewisite Molecule of the Month – May

By using this site, you agree to the Terms of Use and Privacy Policy. Pharmacy and pharmacology portal Medicine portal. Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, [8] and it remains an essential drug. Human and Experimental Toxicology Dimercaprol Edetates Prussian blue. Common side effects include high blood pressurepain at antj site of the injection, vomiting, and fever. Improvements in synthesis resulted in the development of effective therapeutic ointments lewisitd solutions.

Dimercaprol | drug |

Discover some of the most interesting and trending angi of By32 articles had been published or were in press on the therapeutic value of BAL Ord At the bottom of the article, feel free to list any sources that support your changes, so that we can fully understand their context.


Plans for the possible production ofpounds per year were developed Waters and Stock British anti-Lewisite is used in arsenic, gold, and mercury soluble inorganic compounds britisu. Archived PDF from the original on 23 April Lewisite 2-chlorovinyldichoroarsine is an arsenic-based vesicant chemical warfare agent that was initially developed, although not used, by the United States during World War I.

In This Article Introduction.

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Experimental observations revealed that dimercaprol may be an effective neuroprotective agent. It does, however, remove inorganic mercury from the kidneys; but is not leiwsite in the treatment of alkylmercury or phenylmercury toxicity. Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme’s activity.

During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent. Arsenic poisoning Dimercaprol Succimer.

Goals and duration of treatment.

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