Request PDF on ResearchGate | Intérêt des acides biliaires dans la cholestase gravidique | Intrahepatic cholestasis during pregnancy is a risk factor for. La cholestase gravidique a été reliée à des critères de jugement maternels et fœtaux/néonatals indésirables. Du fait que la physiopathologie est mal comprise, . Interventions pour le traitement de la cholestase gravidique. This is not the most recent version of this Review. view the current version 24 June

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Cholestasis of pregnancy presents with pruritus, sometimes incapacitating, less frequently by jaundice. If you want to subscribe to this journal, see our gravidiqur You can purchase this item in Pay Per Cohlestase The disease is probably due to susceptibility to estrogens and progesterone, whose serum concentration is elevated during pregnancy and which are cholestatic.

Access to the text HTML. The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties. The susceptibility is explained by polymorphisms of genes encoding hepatocytic transport proteins that are important for bile secretion.


Journal page Archives Contents list. It is slightly more frequent during twin pregnancies. Treatment by the bile acid ursodeoxycholic acid improves pruritus and decreases the ggavidique of fetal complications, without side effects in the mother or baby. Top of the page – Article Outline. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen.

Hépato-Gastro & Oncologie Digestive

As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data. La cholestase gravidique Intrahepatic cholestasis of pregnancy.

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Besides disturbing pruritus, maternal prognosis is good. Liver tests are abnormal, with mainly an increase in serum transaminases and bile acids.


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Its prevalence in France is of the order of 1 per pregnancies. Personal information regarding our website’s visitors, including their identity, is confidential. Bile acids, Ursodeoxycholic acid, Prematurity, Pruritus.

La cholestase gravidique – EM|consulte

Elle survient pendant le 2 e ou le 3 e trimestre de la grossesse. Access to the full text of this article requires a subscription. Clinical signs and biochemical abnormalities normalize rapidly after delivery, at most after 3 to 4 weeks.

You can move this window by clicking on the headline. In forms with severe pruritus, early delivery by induced labor between 37 and 38 weeks may be necessary. Gravity of the disease comes from the occurrence of fetal complications, in particular prematurity often induced by obstetrical teams and its pulmonary complications, and sudden intra-uterine fetal death. It occurs during the second or third trimester.

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