of pancreatitis from common bile duct obstruction with hyperamylasemia | It is diferencial entre pancreatite aguda/crônica agudizada e outras causas de dor . The differential diagnosis of hyperamylasemia is difficult, but most high levels . diferencial entre pancreatite aguda/crônica agudizada e outras causas de dor. Hyperamylasemia is frequently found in cases of megaesophagus. This is particularly true of those exhibiting enlarged salivary glands; it is present in per.

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You need a subscription to this content to use this feature. Using the literature to evaluate diagnostic tests: Considering these results it can be stated that these are the variables which more significantly differentiate patients who developed high serum lipase from those that did not. The authors therefore proposed to determine the frequency of asymptomatic high serum lipase in critically ill patients, involved risk factors and outcome. Serum amylase and lipase are widely used as markers of pancreatic inflammation; however their elevation is not always predictive of pancreatic disease.

In this series we found this alteration of serum lipase in a significant number of patients, with concomitant elevation of amylase in a smaller number of patients.

Frank B, Causaz K. Several attempts have been made to determine whether amylase is associated with any specific protein in the serum. According to the guidelines of the American College of Gastroenterology ACGdiagnosis of acute pancreatitis requires presence of at least two of the following characteristics: Regarding clinical and analytical characteristics of patients Table 3those that developed high serum lipase more often showed symptoms such as hypotension, hyperthermia, elevation of transaminases and alkaline phosphatase, hyperbilirrubinemia, anemia, hyperglycemia and bacteremia.

Based upon these issues, the authors proposed a study to determine the frequency of high serum lipase causzs critical patients in an intensive care unit and possible factors associated to their elevation, as well as assessment of the severity and clinical evolution of the patients.


Patients were divided into two groups: In these patients, imaging exams may play a very important role to reach a diagnosis.

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J Med Libr Assoc. Indeed, a minority of patients had symptoms that could be those of acute pancreatitis. Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein.

In patients who had parenteral nutrition an elevation of the pancreatic enzymes was found. Propofol-induced hyperamylasaemia in a general intensive care unit. That is to say, no greater gastric stasis or paralytic ileus were found hindering such form of nutrition.

Increased lipase and amilase levels in critically ill patients: retrospective study

Of patients with concomitant hyperamylasemia and high serum lipase, You will be directed to acponline. Patients less than 18 years old and admission of less than 72 hours were also excluded. In terms of mortality no statistically significant differences were found between the two groups. Abdominal ultrasound, even though it is a safe exam, presents limitations for study of the pancreas, notably low sensitivity for diagnosis of high serum lipase inflammation, fluid collections or necrosis.

Submitted on July 1, Accepted on November 10, The use of serum amylase and lipase in evaluating and managing blunt abdominal trauma. Tolerance to enteral nutrition was assessed by presence of gastric stasis. By continuing to use our website, you are agreeing to our privacy policy. Sign In Set Up Account.

Nevertheless we stress that the radiological study had been performed in a small percentage of patients and according to not well explained criteria, limitations inherent to a retrospective study such as this one.

This rise may reflect pancreatic or extra-pancreatic production. Finally, in the discriminating analysis performed Table 5the independent variables were those positively associated to high serum lipase, that is to say, length of stay, fever, elevation in transaminases, parenteral nutrition and mechanical ventilation. Serum lipase levels in nonpancreatic abdominal pain versus acute pancreatitis.


All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. To summarize, elevation of pancreatic enzymes in critically ill patients is a challenge and studies that would explain the clinical significance are scarce.

Abdominal TC scan is the gold standard technique for diagnosis of acute pancreatitis, to confirm diagnosis, exclude alternative diagnoses and determine the severity and presence of complications. Serum amylase and lipase elevation is associated with intracranial events. According to the coefficient obtained, patients with high serum lipase, more frequently receive parenteral nutrition, tend to have a longer stay and develop fever.

Pancreatic abscess following scrub typhus associated with multiorgan failure. To summarize, overall results of this retrospective study were those expected and most often found in references.

Of these patients, In a review of literature few reports on acute pancreatitis in ricketsiosis are found. Sign in below to access your subscription for full content. Etiopatogenia da pancreatite aguda. Pancreatitis; Lipase; Amylases; Intensive care units.

High serum lipase in ventilated patients may related to ischemic phenomena in the pancreatic microcirculation and changes in the vascular tone of the body circulation, including cranial pressure, caused by alterations in blood gases and ventilation induced pressure alterations. When present, these variables focused our attention on the finding of high serum lipase and may help to select patients for whom analysis of these may be really important.