Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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The weight of formulations containing Neusilin and Fujicalin ranged in between 0. Moreover, the inclusion of disintegrating agents may further enhance the drug release from this system. Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption.
Therefore, it was essential to study the flowability of these liquisolid powder admixtures prior to compression. Dissolution parameters of optimized liquisolid compacts and conventional tablets of Olmesartan medoxomil. The thermogram showed a sharp endothermic peak at of From the results of different batches prepared by three different carriers shown in Table 6it was found that Neusilin proved to be the superior carrier than others.
Spireas S, Sadu S Enhancement of prednisolone dissolution properties using liquisolid compacts.
Journal of Drug Delivery
A lesser amount of Neusilin was required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which lowered the weight of tablet. Usually, microcrystalline cellulose and colloidal silica are used as the carrier and the coating material, respectively.
Related article at PubmedScholar Google. This would explain the improved drug dissolution from liquisolid compared to conventional preparations. Home Publications Conferences Register Contact. Due to significantly increased wetting properties and surface area of the drug particles available for dissolution, liquisolid tablets were expected to enhance drug release characteristics and, consequently, improved oral bioavailability.
Due to the many advantages associated with oral route, the poor solubility of such drugs suffers with slow dissolution and poor bioavailability.
On the other hand, if a solid water-insoluble drug is formulated, it should be initially dissolved or suspended in suitable nonvolatile solvent system to produce drug solution or drug suspension of desired concentration. The tensile strength of the tablet was also sufficient. Withdrawn samples were filtered through a 0. IntJ Pharm PharmSci 2: Subscribe to Table of Contents Alerts. Powder flowability is crucial in the industrial production of tablet dosage forms, as a uniform powder stream through hopper confirms uniformity of both tablet weight and drug content.
Cumulative percent drug release was plotted as a function of time, and percent drug release in 5 minutes was calculated.
This indicates that there is no interaction between the drug and excipients. These peaks can be considered as characteristic peaks of olmesartan medoxomil and were not affected and prominently observed in IR spectra of olmesartan compactss along with oil and carrier materials shown in Figure 4 b.
Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
Abstract Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered compqcts. Indexed in Web of Science. Dissolution profile of liquisolid compacts was compared with marketed tablet formulation. However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.
This indicates acceptable resistance was shown by liquisolid tablets to withstand handling. Patil J Liquisolid Compact Technique: International Journal of ChemTech Research 2: View at Google Scholar.
Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International
The liquisolid technology is described by Spireas as liquid may be transformed into a free-flowing, readily compressible, and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material Figure 1. Formulations containing showed good flowability than formulations containing. Journal of Drug Delivery.
The liquid medication is the liqquisolid insoluble drugs carried in suitable non-volatile solvents. The aim of present investigation was to prepare liquisolid compacts of high dose water insoluble drug, carbamazepine CBZ using novel porous carriers such as Neusilin and Fujicalin in order to improve its dissolution rate and reduce the tablet weight.
Olmesartan medoxomil was received as a gift sample from Alembic Pharma Ltd. The flowable liquid retention potential was calculated using the following equation: Figures 3 a and 3 b show the thermogram for olmesartan medoxomil and liquisolid mixture. The and for liquid vehicles were used to calculate.